Eddie Lee, MD, PhD

Associate Professor

Department of Pathology and Laboratory Medicine

edward.lee@pennmedicine.upenn.edu

612 Stellar-Chance Laboratories

Visit the lab website here

The Translational Neuropathology Research Laboratory, led by Dr. Lee, is focused on studying the mechanisms that linke genetic and epigenetic alterations in VCP and C9orf72 which affect downstream neurodegenerative disease pathologies in tauopathies such as FTLD-tau and Alzheimer's disease and TDP-43 proteinopathies such as FTLD-TDP and amyotrophic lateral sclerosis. We use a variety of methods including neuropathology, biochemistry, molecular genetics, transcriptome analyses, cell culture, and mouse modeling to uncover basic mechanisms of neurodegeneration.

Eddie Lee AD plaque and tangle good.jpg

Plaques and tangles characteristic of Alzheimer's Disease. 

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Eddie Lee NFTs.jpg

Neurofibrillary tangles seen in Alzheimer's Disease (pseudocolor in left).