Faculty

Zolt Arany

11-106 Smilow
zarany@pennmedicine.upenn.edu

All aspects of cardiovascular metabolism with applications to heart disease, diabetes, and peripartum cardiomyopathy

Joseph Baur

12-114 Smilow
baur@pennmedicine.upenn.edu

Mechanisms of nutrient-sensing and metabolism in aging, focusing on NAD metabolism and mTOR signaling

Erfei Bi

1156 BRB II/III
ebi@pennmedicine.upenn.edu

Mechanisms of cytokinesis and septin assembly and function

Rotonya Carr

907 BRB II/III
rotonya.carr@pennmedicine.upenn.edu

Dysregulation of hepatic lipid metabolism and insulin signaling in alcoholic liver disease and non-alcoholic fatty liver disease

Carol Deutsch

650A Clinical Research Bldg
cjd@pennmedicine.upenn.edu

Cotranslational acquisition of local secondary, tertiary, and quaternary protein conformations for ion channels

Dennis Discher

129 Towne Bldg
discher@seas.upenn.edu

Cell biophysical approaches to basic and applied topics
ranging from matrix stiffness effects to nuclear sensing and phagocytosis

Joshua Dunaief

305 Stellar-Chance Labs
jdunaief@pennmedicine.upenn.edu

Iron-induced retinal changes with application to age-related macular degeneration and other neurodegenerative diseases

Kevin Foskett

700 Clinical Research Bldg
foskett@pennmedicine.upenn.edu

Calcium transport and signal transduction leading to mechanisms behind Alzheimer’s disease and taste perception

Yale Goldman

615-620 Clinical Research Buildiing
goldmany@upenn.edu

Single molecule fluorescence microscopy and optical traps to investigate structural dynamics of biological machines

Matthew Good

1142 BRB II/III
mattgood@pennmedicine.upenn.edu

Cellular sensing, spatial organization, and organelle assembly

Mark Kahn

11-123 Smilow
markkahn@pennmedicine.upenn.edu

Signaling pathways in cardiovascular biology and disease, including interactions between blood cells and vascular endothelium

Daniel Kelly

11-122 Smilow
dankelly@pennmedicine.upenn.edu

Mitochondrial function in the heart to develop metabolic modulator therapy for heart failure

Vera Krymskaya

211 Stemmler Hall
krymskay@pennmedicine.upenn.edu

PI3K-TSC2-mTOR signaling in rare and common lung diseases, including lymphangioleiomyomatosis (LAM)

Eddie Lee

612 Stellar-Chance Laboratories
edward.lee@pennmedicine.upenn.edu

Genetic/epigenetic alterations in VCP and C9orf72 that affect neurodegenerative diseases like Alzheimer's and ALS

Virginia Lee

Maloney Building 3rd Floor
vmylee@upenn.edu

Biology of α-synuclein, tau and TDP-43 in neurodegenerative diseases like Alzheimer’s, Parksinson’s, and ALS.

Kathy Liu

350 Clinical Research Building
liufg@pennmedicine.upenn.edu

Gene regulation by RNA modifying enzymes and RNA binding proteins, and the biochemical basis of sexual dimorphism

Kenneth Margulies

11-101 Smilow
Kenneth.Margulies@pennmedicine.upenn.edu

Biomechanics, cytoskeletal regulation, and metabolism of heart failure

Mickey Marks

Abramson 816G
marksm@pennmedicine.upenn.edu

Assembly and sorting of integral membrane protein complexes, focusing on their contribution to the biogenesis of lysosome-related organelles like melanosomes

Michael Ostap

740 Clinical Research Building
ostap@pennmedicine.upenn.edu

Cytoskeleton, molecular motors, and signaling pathways in cell migration, muscle contraction, and cellular trafficking

Liming Pei

6018 CTRB
LPei@pennmedicine.upenn.edu

Metabolic regulation and disease

Benjamin Prosser

726 Clinical Research Building
bpros@pennmedicine.upenn.edu

Biomechanics of the heart and therapeutics development for inherited neurodevelopmental disorders

Amita Sehgal

10-136 Smilow
amita@pennmedicine.upenn.edu

Molecular and cellular basis of circadian rhythms and sleep using Drosophila and mammalian models

James Shorter

805 Stellar-Chance Laboratories
jshorter@pennmedicine.upenn.edu

Deleterious phase transitions in ALS/FTD, PD, AD, and related disorders

Paul Titchenell

12-104 Smilow
ptitc@pennmedicine.upenn.edu

Regulation of metabolism by hormones and nutrients, with particular emphasis on insulin

Phong Tran

1153 BRB II/III
tranp@pennmedicine.upenn.edu

Cytoskeleton functions in cell polarity, cell division, and organelle positioning

Other CPM Faculty

Charles S. Abrams - Phospholipid signaling in platelet and T-cells

Yair Argon - Functions of molecular chaperones in modulating cell surface receptors and secreted proteins

Lawrence (Skip) Brass - Basic and translational work in the world of hemostasis and thrombosis

Janis K. Burkhardt - Cytoskeletal dynamics and control of T cell motility, T cell activation, and dendritic cell function

Andrew Dancis - Iron metabolism, iron trafficking, mitochondrial function, heme, and Fe-S proteins

Roberto Dominguez - Structural biology of the actin cytoskeleton

Aron B. Fisher - Reactive oxygen species in cell signaling and oxidative stress in the lung

Ekaterina L. Grishchuk - Molecular mechanisms that produce force and accuracy for mitotic chromosome motions, focusing on kinetochore proteins

Wei Guo - Molecular mechanisms of exocytic trafficking, tumor invasion, and immune suppression

David A. Hill - Immunology, cell and molecular biology, genomics, and transcriptional regulation with a focus on allergy and obesity

Erika Holzbaur - Molecular motors and the cytoskeleton, autophagy and mitophagy, the cell biology of the neuron, and neurodegeneration

Jorge Henao-Mejia - Interactions between the immune system and whole body and cellular metabolism in the context of health and obesity

Paul Janmey - Substrate effects on cell biomechanics

Anna Kashina - Protein arginylation, including structure of ATE1 and identification of ATE1 targets

Tejvir Khurana - High altitude medicine

Melike Lakadamyali - Super-resolution microscopy to study vesicle transport along cytoskeletal tracks and the spatial organization of nucleosomes along chromatin

Michael Lampson - Mechanics of cell division, particularly interactions between chromosomes and spindle microtubules and regulation by mitotic kinases

Robert J. Lee - Epithelial cells that line the airways from the nose to the lung, focusing on GPCR regulation of airway physiology and innate immunity

Elizabeth M. Lennon - Protective role of the mast cell in IBD

Zhe Lu - Mechanisms and regulation of ion channel permeation and gating

Francis Luca - Cell division and cellular morphogenesis, focusing on the Mob protein family

Minghong Ma - Interactions of the olfactory system with non-olfactory regions of the brain

Sandra Lynn Maday - Mechanisms and regulation of autophagy in neuronal homeostasis and neurodegeneration

Claire Mitchell - Lysosomal physiology and purinergic/glutaminergic neurotransmitter systems in ocular health

Akhilesh Reddy - Non-transcriptional/post-translational processes in circadian rhythms like redox and metabolic oscillations

Dejian Ren - Regulation of excitability of the brain, in addition to the biology of endosomes and lysosomes

Jeffrey D. Roizen - Vitamin D metabolism and action

Brian M. Salzberg - Optical measurements of membrane voltage in neurons

John Seykora - Mechanisms of keratinocyte growth and differentiation with application to skin cancer and psoriasis

Tatyana Svitkina - Platinum replica electron microscopy for the study of cytoskeleton structure and dynamics

John W. Weisel - Intermolecular and cellular interactions in blood clotting and atherosclerosis using molecular biophysical methods

Gary D. Wu - Mutualistic interactions between the gut microbiota and the host with a particular focus on metabolism